

Like in The Womb, there are even duplicate bosses, although they are more common now (Especially Loki and Gemini). Like in The Womb, many rooms contain past bosses, but now the bosses are also drawn from The Depths and Womb, as well as the Harbingers. Unlike other chapters, Sheol only has one floor, with Satan as the boss. The walls appear to be the same material found in the Devil Room, most likely a reference to the name of the level, meaning "underworld" in Hebrew. This usually requires 2.0 speed, a long running start and careful positioning to cross the door before its damage effect kicks in, or alternatively several size downs and very careful nudging along the door's edge.Sheol (pronounced "shee-ohl") is a level that was added in the Halloween Update. Isaac can pass through Curse Room doors without taking damage even when he should.

During Cursed! (challenge #10), all doors except for special types turn into this type of door.

This means that Isaac can be damaged by it without actually going through the door, and any effects that occur upon taking damage will occur in the current room and not the room that the door leads to. The damage done by the Curse Room's door is applied when touching the door.If a Secret Room is next to a Curse Room, it can be entered without taking any damage by bombing the wall between these rooms from the Secret Room.Any item that gives Isaac a shield or invulnerability will prevent damage taken when passing through a Curse Room Door, including Holy Mantle.Items that grant flight allow Isaac to avoid damage taken upon entering a Curse Room, but do not prevent damage taken upon leaving.In Greed mode, curse rooms can feature the following things: A Devil statue and a random item or trinket, surrounded by spikes.Curse Rooms can feature the following things:
